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xanthine derivatives uses

The xanthines also have other activities mediated by their effects on different tissue phosphodiesterases including inhibition of platelet function and arterial vasodilation. Xanthines also stimulate muscle and cardiac cells and neurons. The xanthines also are adenosine receptor antagonists. The major use of xanthine derivatives are for relief of bronchospasm caused by asthma or chronic obstructive lung disease. Immediate Release Tablets and Liquids: Take at regular intervals around the clock. Every drug is capable of producing side effects. Pending Application number JP12573978A Other languages Japanese (ja) Inventor Blood levels must be checked regularly to avoid underdosing and overdosing. The xanthines also have other activities mediated by their effects on different tissue phosphodiesterases including inhibition of platelet function and arterial vasodilation. Allopurinol and Febuxostat are xanthine oxidase inhibitor drugs that is used to treat gout and high levels of uric acid in the blood (hyperuricemia) caused by certain cancer medications, and kidney stones. These compounds are alkaloids and include such common mild stimulants as caffeine and theobromine, which is found in chocolate. Sustained, Extended, or Controlled Release Products: Take 8- to 12-hour release products at regular intervals (8 or 12 hours) around the clock. Xanthine derivatives. Brand interchange - Do not change from one brand of this drug to another without consulting your pharmacist or doctor. Theophylline is … This medication works best when taken on an empty stomach one hour before or two hours after meals. Do not use for an acute episode of bronchospasm. Pathology. The following drugs and drug classes interact with xanthine bronchodilators: These drugs increase the effects of xanthine broncobusters (increasing side effects), Beta blockers (nonselective) (eg, propranolol), Carbamazepine (eg, Tegretol cimetidine (eg, Tagamet), Clarithromycin (Biaxin) contraceptives, oral estrogen­containing (eg, Ortho-Novum), Disulfiram (Antabuse) ephedrine (eg, Sudafed), Fluoroquinolones (eg, ciprofloxacin, enoxacin, norfloxacin, ofloxacin), Isoniazid (eg, Laniazidl methotrexate (eg, Rheumatrex), Mexiletine (Mexitil) pentoXifylline (Trental) propafenone (Rythmol) propranolol (eg, lnderal), Tacrine (Cognex) thiabendazole (Mintezol thyroid hormones (eg, levothyroxine). // Build an array initializer For specific medical advice, diagnoses, and treatment, please consult your doctor. } U.S. Pat. This review focuses on the molecular mechanisms involved in the actions of xanthine derivatives with special reference to their adenosine receptor antagonistic properties. Other: Increased urination; high blood sugar; rectal irritation or bleeding (suppository only); muscle tremors or twitching. Because of the worldwide use of these drugs and the recently synthesized xanthine derivatives, an intensive research on the cardiac actions of these substances is under progress. This makes them useful to treat asthma, emphysema, and chronic bronchitis. //-->. isnDays[0]="Sun"; The increase in cAMP causes relaxation of bronchial smooth muscle. US7482337B2 US10/695,597 US69559703A US7482337B2 US 7482337 B2 US7482337 B2 US 7482337B2 US 69559703 A US69559703 A US 69559703A US 7482337 B2 US7482337 B2 US 7482337B2 Note that dyphylline is not converted to theophylline; thus, theophylline blood levels cannot be used to monitor its use. Products are not equivalent on a weight basis and cannot be interchanged without adjusting the dose. Patient Education- Xanthine Derivatives. Keywords:Methylxanthines, xanthine derivatives, adenosine, adenosine receptors, subtype-selectivity, risk/benefit ratio, theophylline, cardiorespiratory disorders, caffeine, electrophysiological Abstract: Methylxanthines, such as theophylline, have been used to treat cardiorespiratory disorders, whereas caffeine is the most widely consumed psychoactive agent in various soft drinks. google_ad_channel ="6145589847"; Theophylline is a xanthine derivative. From: Methods in Enzymology, 2018. function isnArray() { 4,716,165 describes the use of certain theobromine derivatives for treating asthma, allergic rhinitis, atopic dermatitis or eczema. Uniphyl, Theolair SR - Take this drug consistently with respect to food, either with meals or fasting (at least 2 hours pre- or 2 hours post­meals). THE ANTI-ANAPHYLACTIC ACTIVITY OF THEOPHYLLINE AND SOME RELATED XANTHINE DERIVATIVES. In this event, the second dose should be taken 10 to 12 hours after the first dose and before the evening meal. This site needs JavaScript to work properly. Class Summary. It is claimed: 1. google_color_border = "B2BABD"; Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. google_color_link = "FFFFFF"; The vasodilation caused by xanthines has been used to treat intermittent claudication (pentoxifylline). document.write(1900 + thisyear); The xanthines have many minor side effects (anxiety, nervousness, tremor, headache, dizziness) but are largely well tolerated in the doses used to treat asthma and chronic bronchitis. WO 8905145 describes the use of certain xanthine derivatives for the treatment of a wide variety of disease states including psoriasis. The derivatives of xanthine that are used most commonly in medicine have a methyl, or CH3, group on them. HEALTH CARE | ABOUT US | CONTACT US | BLOG. Therapy frequently requires IV medication and close monitoring .These products alone are not appropriate treatment for an acute asthma attack. Pharmaceutical formulations of xanthine or xanthine derivatives, and their use Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Do not make up the the missed dose. Take 24-hour release products once daily, preferably in the morning. No. The major use of xanthine derivatives are for relief of bronchospasm caused by asthma or chronic obstructive lung disease. Bronchial asthma b. Osteoporosis c. Dementia d. Pancreatitis Use only if clearly needed and potential benefits outweigh the possible hazards to the fetus. What might happen: Your adenosine or hexobendine may not work as well. A compound of formula (I): ##STR35## or, if appropriate, a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 each independently are an alkyl group or a moiety of formula (a): --(CH 2) m--A (a). Children: Safety and effectiveness of aminophylline and theophylline for use in children younger than 1 year of age have not been establish Caution should be exercised for younger children who cannot of side effects. The most widely used xanthine is theophylline. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Xanthine has been proposed as a lead for the generation of pharmacologically active compounds. These are very closely related and are to be found in extremely varying contents in different plants.


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